Monday, August 1, 2011

Glucose Homeostasis After Prednisolone Anti-Allergic Therapy

Kovalik M, Thoday KL, Evans H et al. Prednisolone is associated with an increase in serum insulin but not serum fructosamine concentrations in dogs with atopic dermatitis. Veterinary Journal 2011: EPub ahead of print. Abstract
PubMed ID (PMID): 21745752
ReprintR. Mellanby
Comments: This clinical study revealed that prednisolone given at around 1 mg/kg once daily for 7 days then every other day for 5 weeks to 16 dogs had no effect on plasma glucose and serum fructosamine concentrations. In contrast, serum insulin levels were higher after treatment, but only one of 16 values was above the reference range. 
Recommended by: Thierry Olivry, NC State University, Raleigh, North Carolina, USA