Friday, August 24, 2012
Bizikova P, Dean GA, Hashimoto T, Olivry T. Cloning and establishment of canine desmocollin-1 as a major autoantigen in canine pemphigus foliaceus. Vet Immunol Immunopathol. 2012; 149: 197-207. Abstract.
PubMed ID (PMID): 22884397
Comments: A set of studies demonstrate that most dogs affected with pemphigus foliaceus (PF) have circulating anti-desmocollin-1 (DSC-1) IgG autoantibodies. This establishes this desmosomal cadherin as a major target autoantigen in canine PF. This is an important step forward in our understanding of the pathogenesis of this most common autoimmune disease in dogs.