Monday, April 30, 2012

Avermectins and Milbemycins Toxicity


Merola VM, Eubig PA. Toxicology of avermectins and milbemycins (macrocytic lactones). Veterinary Clinics of North America (Small Animal Practice) 2012; 42: 313-333. Abstract.
PubMed ID (PMID): 22381182
ReprintV. Merola
Comments: This paper is an excellent review about the usage of avermectins and milbemycins in dogs and cats. This review explains the mechanism of action and pharmacokinetics of macrocyclic lactones and provides in depth relevant information about P-glycoprotein. Toxic dosages for each medication are also reported. There is a review of all possible drug interactions with macrocyclic lactones, drugs that could be either P-glycoprotein substrates or inhibitors. This paper finishes with the review of current data on intravenous lipid emulsions as a possible therapy for macrocyclic lactone toxicosis. 
Recommended by: Frane Banovic, NC State University, Raleigh, North Carolina, USA