Wednesday, October 26, 2011

Lethal Junctional Epidermolysis Bullosa in Sheep

Ostmeier M, Kerkmann A, Frase R et al. Inherited junctional epidermolysis bullosa (Herlitz type) in German black-headed mutton sheep. Journal of Comparative Pathology 2011; ePub ahead of print. Abstract
PubMed ID (PMID): 22000950
Comments: This second paper from a series of three further describes the clinical, histopathological and ultrastructural characteristics of lethal junctional EB in a German ovine breed. For those interested in molecular genetics, details of the complex mutation of LAMC2, which encodes the gamma-2 chain of laminin-332 (laminin-5), can be found in the open access article in PLoS One (Click here to view)
The first paper of this series provides additional information on the origin of the trait and more in depth clinical and autopsy information (see (Click here for abstract).
Recommended by: Thierry Olivry, NC State University, Raleigh, North Carolina, USA