Popa I, Remoue N, Hoang LT et al. Atopic dermatitis in dogs is associated with a high heterogeneity in the distribution of protein-bound lipids within the stratum corneum. Archives of Dermatological Research 2011; 303: 433-440. Abstract
PubMed ID (PMID): 21240511
Reprint: I. Popa
Comments: this is an important paper that reports, in the stratum corneum of atopic compared to normal dogs, a decrease in the quantities of free and protein-bound ceramides, a concurrent increase in the amounts of glycosylceramides and a variation in ceramide composition among stratum corneum layers. These results suggest a possible abnormal ceramide metabolic pathway in the stratum corneum of dogs with atopic dermatitis, and that successive waves of inflammation might transiently alter stratum corneum lipid biosynthesis.
Recommended by: Thierry Olivry, NC State University, Raleigh, North Carolina, USA
Reprint: I. Popa
Comments: this is an important paper that reports, in the stratum corneum of atopic compared to normal dogs, a decrease in the quantities of free and protein-bound ceramides, a concurrent increase in the amounts of glycosylceramides and a variation in ceramide composition among stratum corneum layers. These results suggest a possible abnormal ceramide metabolic pathway in the stratum corneum of dogs with atopic dermatitis, and that successive waves of inflammation might transiently alter stratum corneum lipid biosynthesis.
Recommended by: Thierry Olivry, NC State University, Raleigh, North Carolina, USA
