Friday, August 24, 2012

Desmocollin-1 is a Major Antigen for Canine Pemphigus Foliaceus

Bizikova P, Dean GA, Hashimoto T, Olivry T. Cloning and establishment of canine desmocollin-1 as a major autoantigen in canine pemphigus foliaceus. Vet Immunol Immunopathol. 2012; 149: 197-207Abstract. 
PubMed ID (PMID): 22884397
ReprintT. Olivry 
Comments: A set of studies demonstrate that most dogs affected with pemphigus foliaceus (PF) have circulating anti-desmocollin-1 (DSC-1) IgG autoantibodies. This establishes this desmosomal cadherin as a major target autoantigen in canine PF. This is an important step forward in our understanding of the pathogenesis of this most common autoimmune disease in dogs.
Recommended by: Svetlana Belova, Estonian University of Life Sciences, Tartu, Estonia