ECVD Article Alert Blog

The purpose of this blog is to alert ECVD Residents and Diplomates to relevant articles normally not published in one of the journals from the syllabus reading list. Important articles from that list might also be highlighted. This list is not meant to be exhaustive. A posting does not imply that the article will serve--or not--as the basis for an examination question. You may suggest any article by emailing its reference to tolivry at ncsu.edu. Happy reading! The Blog Committee

Sunday, July 31, 2011

Effect of Type-1 and Type-4 Antihistamines in Experimental Canine Atopic Skin Lesions

Bäumer W, Stahl J, Sander K et al. Lack of effect of systematically and topically administered histamine H(1) or H(4) receptor antagonists in a dog model of atopic dermatitis. Experimental Dermatology 2011; 20: 577-581. Abstract

PubMed ID (PMID): 21521369
Reprint: T. Olivry
Comments: this study showed that hydroxyzine, cetirizine and two selective type-4 antihistamines were unable to prevent the development of Dermatophagoides farinae-induced skin lesions in mite-sensitized dogs. In contrast, and not surprisingly, topical triamcinolone spray completely prevented the development of skin lesions.
Recommended by: Thierry Olivry, NC State University, Raleigh, North Carolina, USA